International Journal of Medicinal Chemistry / 2012 / Article / Tab 3

Research Article

Syntheses and In Vitro Biological Activity of Some Derivatives of C-9154 Antibiotic

Table 3

Minimum Inhibitory Concentration (above) and Minimum Bactericidal/Fungicidal Concentration (below) of the analogue and derivatives (μg/mL).

IA/12/1IA/27/1/BIA/28/1/BIA/29/1/BIA/30/1/BIA/31/1/BIA/32/1/BDMSOSparfloxacinFluconazole

MRSA2.5
5
0.625
2.5
0.625
2.5
0.625
5
0.625
2.5
0.625
2.5
0.625
5
ND10ND
S. aureus 2.5
5
0.625
5
1.25
5
0.625
2.5
0.625
2.5
0.625
5
0.625
2.5
ND10ND
S. pyogenes 2.5
10
0.625
2.5
0.625
2.5
ND
ND
1.25
5
0.625
5
0.625
2.5
ND10ND
B. subtilis 1.25
5
0.625
1.25
0.625
1.25
0.625
2.5
0.625
2.5
0.625
2.5
1.25
5
ND5ND
C. ulcerans 2.5
10
ND
ND
0.625
5
0.625
2.5
0.625
5
ND
ND
ND
ND
NDNDND
E. coli 2.5
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
ND10ND
P. mirabilis 2.5
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
ND10ND
P. aeruginosa ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND10ND
S. typhii 2.5
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
ND10ND
S. dysenteriae 1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
ND5ND
K. pneumoniae 1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
ND5ND
C. albicans 2.5
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
1.25
5
NDND25
A. nigre 2.5
10
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
NDNDND
T. rubrum ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
ND
NDND25

Upper values are MIC and lower values are MBC or MFC as the case may be. ND: Not Determined.

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