Table of Contents Author Guidelines Submit a Manuscript
International Journal of Medicinal Chemistry
Volume 2013, Article ID 197612, 5 pages
http://dx.doi.org/10.1155/2013/197612
Research Article

Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents

Laboratory of Heterocycles, School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain, Madhya Pradesh 456010, India

Received 25 October 2012; Revised 31 January 2013; Accepted 17 March 2013

Academic Editor: Qidong You

Copyright © 2013 Anjna Bhatewara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. O. Kappe, “100 years of the Biginelli dihydropyrimidine synthesis,” Tetrahedron, vol. 49, no. 32, pp. 6937–6963, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. G. C. Rovnyak, S. D. Kimball, B. Beyer et al., “Calcium entry blockers and activators: conformational and structural determinants of dihydropyrimidine calcium channel modulators,” Journal of Medicinal Chemistry, vol. 38, no. 1, pp. 119–129, 1995. View at Google Scholar · View at Scopus
  3. A. D. Patil, N. V. Kumar, W. C. Kokke et al., “Novel alkaloids from the sponge Batzella sp.: inhibitors of HIV gp120-human CD4 binding,” Journal of Organic Chemistry, vol. 60, no. 5, pp. 1182–1188, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Borse, P. Mahesh, P. Nilesh, and S. Rohan, “A green, expeditious, one-pot synthesis of 3, 4-dihydropyrimidin-2(1H)-ones using a mixture of phosphorus pentoxide-methanesulfonic acid at ambient temperature,” ISRN Organic Chemistry, vol. 2012, Article ID 415645, 6 pages, 2012. View at Publisher · View at Google Scholar
  5. D. Abdelmadjid, C. Louisa, B. Raouf, and C. Bertrand, “A one-pot multi-component synthesis of dihydropyrimidinone/thione and dihydropyridine derivatives via Biginelli and Hantzsch condensations using t-BuOK as a catalyst under solvent-free conditions,” The Open Organic Chemistry Journal, vol. 6, pp. 12–20, 2012. View at Google Scholar
  6. T. Reza, M. Behrooz, and G. Malihe, “Ammonium dihydrogen phosphate catalyst for one-pot synthesis of 3, 4-dihydropyrimidin-2(1H)-ones,” Chinese Journal of Catalysis, vol. 33, no. 4–6, pp. 659–665, 2012. View at Google Scholar
  7. S. Agarwal, U. Aware, A. Patil et al., “Silica-gel catalyzed facile synthesis of 3, 4-dihydropyrimidinones,” Bulletin of Korean Chemical Society, vol. 33, no. 2, pp. 377–378, 2012. View at Google Scholar
  8. R. Hekmatshoar, M. Heidari, M. M. Heravi, and B. Baghernejad, “Mesoporous molecular sieve MCM-41 catalyzed one-pot synthesis of 3,4-dihydro-2(1H)-pyrimidinones and -thiones under solvent-free conditions,” Bulletin of the Chemical Society of Ethiopia, vol. 25, no. 2, pp. 309–313, 2011. View at Google Scholar · View at Scopus
  9. J. A. Kumar, C. Shanmugam, and P. H. Babu, “One pot synthesis of dihydropyrimidinones catalyzed by Cyanuric chloride: an improved procedure for the Biginelli reaction,” Der Pharma Chemica, vol. 3, no. 4, pp. 292–297, 2011. View at Google Scholar
  10. B. F. Mirjalili, A. Bamoniri, and A. Akbari, “One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones (thiones) promoted by nano-BF3 · SiO2,” Journal of the Iranian Chemical Society, vol. 8, supplement 1, pp. S135–S140, 2011. View at Google Scholar · View at Scopus
  11. M. Zeinali-Dastmalbaf, A. Davoodnia, M. M. Heravi, N. Tavakoli-Hoseini, A. Khojastehnezhad, and H. A. Zamani, “Silica gel-supported polyphosphoric acid (PPA-SiO2) catalyzed one-pot multi-component synthesis of 3, 4-dihydropyrimidin-2(1H)-ones and -thiones: an efficient method for the Biginelli reaction,” Bulletin of the Korean Chemical Society, vol. 32, no. 2, pp. 656–658, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. C. V. Reddy, M. Mahesh, P. V. K. Raju, T. R. Babu, and V. V. N. Reddy, “Zirconium(IV) chloride catalyzed one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones,” Tetrahedron Letters, vol. 43, no. 14, pp. 2657–2659, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Y. Fu, Y. F. Yuan, Z. Cao, S. W. Wang, J. T. Wang, and C. Peppe, “Indium(III) bromide-catalyzed preparation of dihydropyrimidinones: improved protocol conditions for the Biginelli reaction,” Tetrahedron, vol. 58, no. 24, pp. 4801–4807, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Shaabani and A. Bazgir, “Microwave-assisted efficient synthesis of spiro-fused heterocycles under solvent-free conditions,” Tetrahedron Letters, vol. 45, no. 12, pp. 2575–2577, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. M. M. Abelman, S. C. Smith, and D. R. James, “Cyclic ketones and substituted α-keto acids as alternative substrates for novel Biginelli-like scaffold syntheses,” Tetrahedron Letters, vol. 44, no. 24, pp. 4559–4562, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Kidwai, K. Singhal, and S. Kukreja, “One-pot green synthesis for pyrimido[4,5-d]pyrimidine derivatives,” Zeitschrift fur Naturforschung B, vol. 62, no. 5, pp. 732–736, 2007. View at Google Scholar · View at Scopus
  17. M. Kidwai, “Dry media reactions,” Pure and Applied Chemistry, vol. 73, no. 1, pp. 147–151, 2001. View at Google Scholar · View at Scopus
  18. M. B. Patil, S. S. Jalalpure, H. J. Pramod, and F. V. Manvi, “Antiinflammatory activity of the leaves of Anacardium occidentale linn,” Indian Journal of Pharmaceutical Sciences, vol. 65, no. 1, pp. 70–72, 2003. View at Google Scholar · View at Scopus
  19. N. K. Jain, M. K. Chourasia, S. Jain, S. K. Jain, and N. K. Jain, “Development and characterization of engineered commensal bacteria for the delivery of enzymes,” Indian Journal of Pharmaceutical Sciences, vol. 65, no. 2, pp. 113–121, 2003. View at Google Scholar
  20. A. R. Saundane, K. Rudresh, N. D. Satyanarayan, and S. P. Hiremath, “Pharmacological screening of 6H, 11H-indolo [3, 2-c] isoquinolin-5-ones and their derivatives,” Indian Journal of Pharmaceutical Sciences, vol. 60, no. 6, pp. 379–383, 1998. View at Google Scholar · View at Scopus
  21. T. Kadre, S. R. Jetti, A. Bhatewara, P. Paliwal, and S. Jain, “Green protocol for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones using TBAB as a catalyst and solvent free condition under microwave irradiation,” Archives of Applied Science Research, vol. 4, no. 2, pp. 988–993, 2012. View at Google Scholar