Research Article

Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors

Figure 2

Androstene hormone activation of the human androgen receptor. Reporter cells were treated with androstene hormone metabolites , incubated for 24 hours, and then assayed for luciferase activity. Androstene hormone activity was normalized to cellular uptake (Section 2.3.1). Error bars, ±1 SD. Statistical significance, from all less activating androstene hormone metabolites (¤), from less activating androstene hormone metabolites ( ).
203606.fig.002