Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors

Figure 3

Androstene hormone activation of the human estrogen receptor beta. Reporter cells were treated with androstene hormones (𝑛=3), incubated for 24 hours, and then assayed for luciferase activity. Androstene hormone activity was normalized to cellular uptake (Section 2.3.1). Error bars, ±1 SD. Statistical significance, 𝑃<0.001 (¤) versus androstene hormone metabolites in the same treatment group, 𝑃<0.001 (∗) versus lower reacting androstene hormones in the same treatment group.