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International Journal of Medicinal Chemistry
Volume 2013, Article ID 273534, 4 pages
http://dx.doi.org/10.1155/2013/273534
Research Article

Catalyst-Free Synthesis of Highly Biologically Active 5-Arylidene Rhodanine and 2,4-Thiazolidinedione Derivatives Using Aldonitrones in Polyethylene Glycol

Department of Chemistry, Punjabi University, Patiala, Punjab 147002, India

Received 11 December 2012; Accepted 14 January 2013

Academic Editor: Armando Rossello

Copyright © 2013 Dhruva Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A green, efficient synthesis of 5-arylidene rhodanine and 2,4-thiazolidinedione derivatives without using any external catalyst in polyethylene glycol (PEG) at 80°C has been described. Reaction procedure is very simple, short, and obtained yields are very high.