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International Journal of Medicinal Chemistry
Volume 2013, Article ID 984329, 7 pages
http://dx.doi.org/10.1155/2013/984329
Research Article

Synthesis and In Vitro Cytotoxic Activity of Chromenopyridones

1Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India
2Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India

Received 19 October 2012; Revised 27 November 2012; Accepted 11 December 2012

Academic Editor: Giulio Rastelli

Copyright © 2013 Balwinder Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Novel substituted chromenopyridones (3aj and 6ad) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.