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International Journal of Medicinal Chemistry
Volume 2014 (2014), Article ID 614808, 18 pages
http://dx.doi.org/10.1155/2014/614808
Review Article

Synthesis and Structural Activity Relationship Study of Antitubercular Carboxamides

1Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka 410002, Nigeria
2Department of Chemical Sciences, Federal University, Wukari, Nigeria

Received 21 August 2014; Revised 21 November 2014; Accepted 30 November 2014; Published 30 December 2014

Academic Editor: Arie Zask

Copyright © 2014 D. I. Ugwu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The unusual structure and chemical composition of the mycobacterial cell wall, the tedious duration of therapy, and resistance developed by the microorganism have made the recurrence of the disease multidrug resistance and extensive or extreme drug resistance. The prevalence of tuberculosis in synergy with HIV/AIDS epidemic augments the risk of developing the disease by 100-fold. The need to synthesize new drugs that will shorten the total duration of effective treatment and/or significantly reduce the dosage taken under DOTS supervision, improve on the treatment of multidrug-resistant tuberculosis which defies the treatment with isoniazid and rifampicin, and provide effective treatment for latent TB infections which is essential for eliminating tuberculosis prompted this review. In this review, we considered the synthesis and structure activity relationship study of carboxamide derivatives with antitubercular potential.