A Predictive HQSAR Model for a Series of Tricycle Core Containing MMP-12 Inhibitors with Dibenzofuran Ring

Table 3

Predicted activities for the molecules based on the HQSAR model. Activities were shown as pIC₅₀ (μM).

Name	R	Predicted pIC50 values	SE of prediction	Normalized mean distance score	Docking score
n1		4.182	0.158579	0.161	−12.038972
n2		3.89	0.097741	0.076	−13.92
n3		3.942	0.093502	0.072	−13.87
n4		3.846	0.308627	0.291	—^a
n5		4.003	0.325568	0.315	—^a
20 (observed = 4)		4.032	—	0.043	−13.7908
19 (observed = 3.3979)		3.706	—	0.037	−12.555956
26 (observed = 3)		2.945	—	0.009	−11.781243

Docking was not performed for these compounds.