Research Article

Molecular Modeling Studies of Thiophenyl C-Aryl Glucoside SGLT2 Inhibitors as Potential Antidiabetic Agents

Table 1

Structure and biological activity of thiophenyl derivatives hSGLT2 inhibitors.

S. numberXRIC50pIC50

1Cl86.57.0629
2Cl34.67.4609
3*Cl1406.8538
4Cl65.07.1870
5Cl54.67.2628
6*Cl1116.9546
7Cl947.0268
8Cl1156.9393
9Cl70.77.1505
10*Cl12.87.8927
11Cl48.47.3151
12Cl11.97.9244
13Cl57.27.2426
14*Cl1626.7904
15Cl60.27.2204
16Cl4.478.3496
17Cl10.37.9871
18Cl91.37.0395
19*H11.57.9393
20H8.738.0589
21H50.27.2992
22*H27.57.5606
23H21.17.6757
24H71.47.1463
25*H68.97.1617
26H4516.3458
27H88.37.0540
28H69.67.1573
29*H24.87.6055
30H59.87.2232
31Br12.47.9065
32OMe49.57.3053
33*Me29.37.5331

Structures with (*) are included in test set validation.