Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors

Table 1

Radical scavenging assay of cinnamoyl esters (8a–h) and amides (9a–h) and caffeoyl esters (15a–h) and amides (16a–h).

Compounds	Radical scavenging; IC50 (𝜇M) [SD]	Compounds	Radical scavenging; IC50 (𝜇M) [SD]
8a–h	>100	9a–h	>100
15a	9.55 [0.3]	16a	15.4 [0.15]
15b	9.37 [0.21]	16b	12.1 [0.18]
15c	9.3 [0.11]	16c	9.87 [0.06]
15d	8.7 [0.47]	16d	11.2 [0.17]
15e	15.1 [2.26]	16e	10.5 [0.24]
15f	9.01 [0.31]	16f	13 [0.61]
15g	9.4 [0.24]	16g	12.01 [0.14]
15h	8.85 [0.05]	16h	18.1 [1.2]
Zileuton 1	>100	3	12 [0.1]
CAPE 2	16.5 [4]	4	13.4 [0.15]
Ascorbic acid	75.4 [4.1]