Design and Synthesis of Novel Antileishmanial Compounds

Figure 7

A comparison of rotatability of compounds 11, 28, 29, and 30, with diverse terminal substituents. 29 and 30 possess only one C,N-axis (rotatability shown in red curved arrows) in comparison to the two-armed compounds 11 and 28; the quinoline nitrogen atom of compound 11 could form intermolecular hydrogen bonds (shown as green straight arrows), whereas the rotatability in compound 28 might be restricted possibly due to the formation of intramolecular hydrogen bond interactions (pink-colored).