Design and Synthesis of Novel Antileishmanial Compounds

Table 3

Plain open-chain aliphatic analogs with N-benzyl-3,3-dimethylbutanamide functionality; given bioactivities are against promastigotes of L. major in comparison to the reference substances miltefosine (1) and pentamidine (2).

Compound	R^1	R^2	Bioactivity
31			Inactive
32	Me	Br	Active
33	=CH2	H	Not determined
34	Me	N3	Active
35	Me	NH2	Inactive