Design and Synthesis of Novel Antileishmanial Compounds

Table 4

Pharmacophore analogs with a phthalimide functionality; given bioactivities are against promastigotes of L. major in comparison to the reference substances miltefosine (1) and pentamidine (2).

Compound	R^1	R^2	Bioactivity
36	Me	Br	Inactive
37	=CH2	H	Inactive
38	Me		Inactive
39	Me	N3	Inactive