A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model
Table 10
Ligands with potent affinity for ; ligands bound with values <20 nM at this subtype. The structures of these ligands are in the Ph.D. thesis of Clayton (2011) [22].
Cook code
CM-D45 C19H21N3O4
90.5
65.5
30.3
0.15
1.65
0.23
CM-D44
34.3
56.3
20.7
0.33
0.57
0.92
JYI-04 (C21H23N3O3)
28.3
16
ND
ND
0.51
1.57
PZII-028
0.2
ND
0.2
ND
0.32
1.9
PWZ-009A1
1.34
1.31
1.26
ND
0.84
2.03
JYI-01 (C19H20N3O3Br)
59.2
159
96
ND
10.6
2.88
JYI-03 (C21H21N3O3)
185.4
107
ND
ND
0.954
3.34
Ro15-4513
3.3
2.6
2.5
ND
0.26
3.8
TG-4-29
2.8
3.9
2.7
2.1
0.18
3.9
JYI-11 (C22H22N3O3F3Si)
5000
5000
ND
ND
648
3.97
QH-II-077
0.06
0.08
0.05
ND
0.12
4
ZG-63A
17.3
21.6
29.1
ND
0.65
4
ZG-208
9.7
11.2
10.9
ND
0.38
4.6
OMB-18
3.9
1.2
3.4
1733
0.8
5
RY-024 C19H19N3O3
26.9
26.3
18.7
ND
0.4
5.1
ZG-234
7.25
22.14
9.84
ND
0.3
5.25
XHE-III-74
77
105
38
0.42
2.2
5.8
JYI-12 (C19H16N3O3F3)
91
39
ND
ND
4.5
6.8
DM-239
1.5
ND
0.53
ND
0.14
6.89
XHE-III-14
2.6
ND
10
13
2
7
TG-4-29
8.3
10.2
6.9
ND
0.4
7.61
DM-215
6.74
ND
7.42
ND
0.293
8.28
JYI-13 (C21H16N3O4F3)
5000
63.7
ND
ND
16
8.38
CGS9895
0.21
ND
ND
ND
ND
9.3
ZG-168
11.2
10.7
9.2
ND
0.47
9.4
PWZ-007A
0.11
0.1
0.09
ND
0.2
10
PZII-029
0.34
ND
0.79
ND
0.52
10
XHE-II-024
0.09
0.18
0.32
14
0.24
11
XHE-II-002
8.3
18
13
3.9
1.5
11
BRETAZENIL
0.35
0.64
0.2
ND
0.5
12.7
JYI-19 (C23H23N3O3S)
2.176
205
ND
ND
34
12.7
SVO-8-14
8
25
8
6.9
0.9
14
SVO-8-30
1.1
5.3
5.3
2.8
0.6
15
WYS10 C14H9F3N2O2
0.88
36
25.6
ND
548.7
15.3
QH-II-090 (CGS-8216)
0.05
0.08
0.12
ND
0.25
17
PWZ-0071
0.23
0.17
0.12
0.44
17.31
The affinity of compounds at /BzR recombinant subtypes was measured by competition for [3H]flunitrazepam binding to HEK cell membranes expressing human receptors of compositions 132, 232, 332, 432, 532, and 632 [139]. Data represent the average of at least three determinations with a SEM of ±5%. ND: not determined.
