A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model

Table 3

Binding affinity at αβ2γ2 receptor subtypes (values are reported in nM).

Compound	α1	α2	α3	α4	α5	α6
SH-053-R-CH3, (15)	2026	2377	1183	>5000	949.1	>5000
SH-053-S-CH3, (16)	1666	1263	1249	>5000	206.4	>5000
SH-053-2′F-R-CH3, (2)	759.1	948.2	768.8	>5000	95.17	>5000
SH-053-2′F-S-CH3, (17)	350	141	1237	>5000	19.2	>5000

Data shown here are the means of two determinations which differed by less than 10%.