Research Article
Design and Synthesis of Novel Hybrid Molecules against Malaria
Scheme 3
Synthetic route for hybrid molecule 13, a piperazine-linked primaquine-chloroquine dual molecule. Reagents and conditions: (a) Boc2O, DCM (dry), 0°C; (b) SOCl2, 80°C; (c) NaOAc, DCM (dry), 0–25°C; (d) 6-methoxy-8-aminoquinoline (4), NaH, DMF (dry), 0–25°C; (e) TFA, DCM, 25°C; (f) 4,7-dichloroquinoline, neat, 120°C.