Design and Synthesis of Novel Hybrid Molecules against Malaria

Scheme 8

Bioactive molecules of the study, reference drugs (1, 2, 3, and 4), and their combinations (, ) in order from the highest to the lowest activities (referring to IC₅₀ values for 3D7, Dd2, and K1, gametocytaemia, and number and diameter of the liver stages, resp.); in brackets the ratios of activities of the compounds compared to the former substances.