Benzyl-1,2,4-triazoles as CB₁ Cannabinoid Receptor Ligands: Preparation and In Vitro Pharmacological Evaluation

Scheme 3

Reagents: (i) benzyl bromide for 7a-7b, 10a-10b, and 13a; 4-chlorobenzyl chloride for 8a-8b, 11a-11b, and 14a-14b; and 2,4-dichlorobenzyl chloride for 9a-9b, 12a-12b, and 15a-15b; 40% NaOH aq, Bu₄NBr, and toluene, 80°C.