Synthesis, In Vivo Anti-Inflammatory Activity, and Molecular Docking Studies of New Isatin Derivatives

Table 1

Physical data of the newly synthesized compounds (VIIa–j). See Scheme 1.

S. number	Compounds	R1	R2	Mol. F	Mol. wt.	M.P (°C)	% yield
1	VIIa	H	H	C15H11N3O3	281	290–292	88
2	VIIb	5-CH3	H	C16H13N3O3	295	285–287	84
3	VIIc	5-Cl	H	C15H10N3O3Cl	315	294–296	82
4	VIId	5-Br	H	C15H10N3O3Br	360	302–306	86
5	VIIe	5-COOH	H	C16H11N3O5	325	286–288	84
6	VIIf	H	N-CH3	C16H13N3O3	295	180–182	82
7	VIIg	H	N-COCH3	C17H13N3O4	323	152–155	72
8	VIIh	7-COOH	H	C16H11N3O5	325	287–289	82
9	VIIi	7-Cl	H	C15H10N3O3Cl	315	295–297	78
10	VIIj	7-Br	H	C15H10N3O3Br	360	300–302	75