Synthesis and Anti-Inflammatory Activity of Some O-Propargylated-N-acetylpyrazole Derived from 1,3-Diarylpropenones
Table 1
Anti-inflammatory potential of test compounds (4a–j and 5a–j) on carrageenan-induced rat paw edema (mL), % protection, and relative activity to indomethacin.
Tested compounds
Increase in paw edema (mL) ± SEM
% protection
Relative activity to indomethacin
Control
0.94 ± 0.018
0.0
0.0
Indomethacin
0.24 ± 0.015
74.5
100
4a
0.23 ± 0.023
75.5
101.3
4b
0.23 ± 0.014
75.5
101.3
4c
0.27 ± 0.021
71.3
95.7
4d
0.64 ± 0.019
31.9
42.8
4e
0.21 ± 0.017
77.7
104.2
4f
0.76 ± 0.024
19.1
25.6
4g
0.22 ± 0.012
76.6
102.8
4h
0.55 ± 0.021
41.5
55.7
4i
0.54 ± 0.016
42.6
57.2
4j
0.68 ± 0.029
24.4
32.8
5a
0.38 ± 0.020
59.6
80
5b
0.32 ± 0.027
66.0
88.6
5c
0.37 ± 0.021
60.6
81.3
5d
0.71 ± 0.015
24.5
32.9
5e
0.22 ± 0.013
76.6
102.8
5f
0.78 ± 0.014
17.0
22.8
5g
0.43 ± 0.022
54.3
72.9
5h
0.73 ± 0.022
22.3
29.9
5i
0.71 ± 0.023
24.4
32.8
5j
0.75 ± 0.022
20.2
27.1
SEM denotes the standard error of the mean. All data are significantly different from control ().