Research Article

Synthesis and Anti-Inflammatory Activity of Some O-Propargylated-N-acetylpyrazole Derived from 1,3-Diarylpropenones

Table 1

Anti-inflammatory potential of test compounds (4a–j and 5a–j) on carrageenan-induced rat paw edema (mL), % protection, and relative activity to indomethacin.

Tested compoundsIncrease in paw edema (mL) ± SEM% protectionRelative activity to indomethacin

Control0.94 ± 0.0180.00.0
Indomethacin0.24 ± 0.01574.5100
4a0.23 ± 0.02375.5101.3
4b0.23 ± 0.01475.5101.3
4c0.27 ± 0.02171.395.7
4d0.64 ± 0.01931.942.8
4e0.21 ± 0.01777.7104.2
4f0.76 ± 0.02419.125.6
4g0.22 ± 0.01276.6102.8
4h0.55 ± 0.02141.555.7
4i0.54 ± 0.01642.657.2
4j0.68 ± 0.02924.432.8
5a0.38 ± 0.02059.680
5b0.32 ± 0.02766.088.6
5c0.37 ± 0.02160.681.3
5d0.71 ± 0.01524.532.9
5e0.22 ± 0.01376.6102.8
5f0.78 ± 0.01417.022.8
5g0.43 ± 0.02254.372.9
5h0.73 ± 0.02222.329.9
5i0.71 ± 0.02324.432.8
5j0.75 ± 0.02220.227.1

SEM denotes the standard error of the mean. All data are significantly different from control ().