Synthesis and Evaluation of Mannitol-Based Inhibitors for Lipopolysaccharide Biosynthesis

Figure 2

The enzyme GmhB is a dephosphatase that cleaves the phosphate in position C-7 of D-glycero-β-D-manno-heptose 1,7-bisphosphate (1). The enzyme also shows activity for fructose 1,6-bisphosphate (2). Compounds 3 and 4 were synthesized as analogs to compound 2.