Syntheses and Antibiotic Evaluation of 2-[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonylbenzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues

Table 3

Minimum inhibitory concentration (MIC) (μg/mL).

Test organism	Z1	Z2	Z3	Z5	Z7	Z8	Z9	Z10	Z11	Z12
MRS	12.50	6.2	—	—	6.2	6.2	—	6.2	6.2	—
VRE	—	6.2	—	6.2	—	12.5	12.5	6.2	—	12.5
S. aureus	6.2	12.5	12.5	—	6.2	6.2	—	6.2	6.2	12.5
S. pyogenes	12.5	6.2	6.2	6.2	—	—	12.5	—	—	12.5
C. ulcerans	—	12.5	12.5	—	12.5	—	6.2	6.2	—	—
E. coli	6.2	6.2	12.5	6.2	12.5	12.5	6.2	—	6.2	12.5
P. vulgaris	—	—	12.5	6.2	12.5	—	—	—	12.5	6.2
P. aeruginosa	—	12.5	—	12.5	—	—	12.5	6.2	—	12.5
K. pneumonia	6.2	6.2	6.2	—	6.2	6.2	6.2	6.2	6.2	6.2
S. typhi	—	—	12.5	—	—	—	12.5	6.2	—	12.5
S. dysenteriae	6.2	6.2	—	6.2	6.2	12.5	12.5	—	12.5	—
C. albicans	12.5	—	6.2	12.5	12.5	6.2	12.5	6.2	6.2	6.2
C. krusei	6.2	6.2	—	12.5	—	12.5	12.5	6.2	12.5	6.2
C. tropicalis	—	12.5	—	12.5	6.2	12.5	12.5	6.2	12.5	12.5
C. stellatoidea	12.5	6.2	6.2	6.2	—	6.2	12.5	6.2	6.2	12.5

—: no MIC.