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International Journal of Medicinal Chemistry
Volume 2016 (2016), Article ID 9706753, 16 pages
http://dx.doi.org/10.1155/2016/9706753
Review Article

A Review on Platensimycin: A Selective FabF Inhibitor

Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura 799022, India

Received 14 October 2015; Revised 25 December 2015; Accepted 31 December 2015

Academic Editor: Maria Cristina Breschi

Copyright © 2016 Manik Das et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Emerging resistance to existing antibiotics is an inevitable matter of concern in the treatment of bacterial infection. Naturally occurring unique class of natural antibiotic, platensimycin, a secondary metabolite from Streptomyces platensis, is an excellent breakthrough in recent antibiotic research with unique structural pattern and significant antibacterial activity. β-Ketoacyl-(acyl-carrier-protein (ACP)) synthase (FabF) whose Gram-positive bacteria need to biosynthesize cell membranes is the target of inhibition of platensimycin. So, isolation, retrosynthetic analysis, synthesis of platensimycin, and analogues of platensimycin synthesized till today are the objectives of this review which may be helpful to further investigate and to reveal untouched area on this molecule and to obtain a potential antibacterial lead with enhanced significant antibacterial activity.