Review Article
A Review on Platensimycin: A Selective FabF Inhibitor
Scheme 2
Synthesis of tetracyclic cage. (i) LDA, (ii) LDA, (iii) DIBAL-H, then HCl, (iv) TBSCL, (v) [CpRu(MeCN)3]PF6, (vi) LiHMDS, TMSCl, (vii) Pd(OAc)2, (viii) HCl aq., (ix) Sml2, HFlP, (x) TFA, (xi) KHMDS, MeI, (xii) KHMDS, (xiii) Me3NO, and (xiv) NaClO2.