Review Article

A Review on Platensimycin: A Selective FabF Inhibitor

Scheme 5

Synthesis of tetracyclic cage. (i) CeCl3, (ii) PCC, and (iii) Hg(OAc)2, then NaBH4, (iv) Martin’s sulfurane, (v) TMSCl, Lil HMDS, and then PhSeCl, (vi) H2O2, Py, (vii) AcOH, MW, (ix) Sml2, (x) DIAD, ArCO2H, PPh3, Ar=p-NO2C6H4, (xi) KOH, (xii) L-selectride (H3O+), (xiii) PCC, (xiv) TMSCl, Lil HMDS, and (xv) IBX or Pd(OAc)2.