Review Article
A Review on Platensimycin: A Selective FabF Inhibitor
Scheme 7
Synthesis of tetracyclic cage. (i) allylBBr2, then HOOH NaOH, (ii) t-BuOOH, VO(sese)2, (iii) Dess-Martin, periodinane, (iv) Silica gel, (v) TBSCl imidazole/BzCl, Py, (vi) PMSOTf (cat.) (TMSOCH2)2, (vii) aqNaOH separation of diastereomers, (viii) PdCl2 Cu(OAc)2 DMA, O2, (ix) KHMDS, (x) Pd(OAc)2(PPh3)2 HCOOH, Bu3N, (xi) PhSH, (xii) Bu3SnH AIBN toluene, reflux, and (xiii) 1N aq HCL.