International Journal of Medicinal Chemistry / 2017 / Article / Fig 6

Research Article

Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics

Figure 6

The IFN-gamma production by splenocytes after activation with 0.1 µg/mL anti-CD3 and when treated with vehicle, 1 µM CGS, and 1 µM CGS plus 1 µM compounds 29, 2 (KW-6002), 3 (KW-PEG), and 4 (preladenant) separately is shown. The IFN-gamma levels were determined in the supernatant one day following stimulation using quantitative ELISA and are expressed as pg/mL. Data shown represent mean ± SEM of triplicate samples.

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