Fluorinated Adenosine A_2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics

Table 1

Physicochemical properties and docking results of compounds 27–29.

Compound	Glide score		Aqueous solubility (μM)	Human PPB (%)	HLM CLint (μL/min/mg)	Rat hepatocyte CLint (μL/min/10^6)
27	−12.2	2.8	74	99	16.5	29.9
28	−11.8	2.5	2	98.7	71.9	12.8
29	−12.3	2.3	10	98.3	66.1	72.9