Correlation between Virtual Screening Performance and Binding Site Descriptors of Protein Targets

Table 2

Average of AUC of the ROC curve and EF at different level obtained with each scoring approach (: AutoDock Vina, : ChemScore, : DrugScore, and : AutoDock 4.2).

Scoring	AUC	EF20%	EF10%	EF2%	EF1%	EF0.2%	EF0.1%
	0.671	2.137	2.93	6.394	8.576	11.17	12.74
	0.61	1.855	2.33	3.567	4.007	4.513	3.54
	0.65	1.942	2.72	5.253	6.275	8.766	9.242
	0.623	1.831	2.5	4.441	4.949	7.301	8.866
	0.668	2.162	3.08	6.714	8.173	8.753	10.01
	0.667	2.174	3.01	6.537	8.768	9.746	9.515
	0.677	2.2	3.21	7.096	9.169	11.72	14
	0.661	2.088	3.01	5.989	7.25	8.371	7.76
	0.652	2.068	2.84	5.158	6.086	7.41	7.47
	0.656	2.087	2.93	6.233	7.28	7.564	7.415
	0.679	2.14	3.08	7.026	9.292	13.21	14.76
	0.671	2.192	3.05	6.074	8.562	11.72	15.66
	0.646	2.012	2.77	4.916	5.986	6.896	6.06
	0.631	1.895	2.53	4.322	5.057	7.324	6.865
	0.658	2.026	2.85	5.579	7.182	8.688	8.51