Crystallography and Its Impact on Carbonic Anhydrase Research

Table 1

Crystal structures of catalytically active human CA isoforms.

	CA I	CA II	CA III	CA IV	CA VI	CA VII	CA IX	CA XII	CA XIII	CA XIV
Structures in PDB	24	703	5	10	1	2	6	16	13	2
PDB ID	2CAB	3KS3	1Z93	1ZNC	3FE4	3MDZ	5DVX	1JCZ	3D0N	4LU3
Resolution (Å)	2.0	0.9	2.1	2.8	1.9	2.3	1.6	1.6	1.6	2.0
Space group	P212121	P21	P65	C2	P212121	C2221	P212121	C2	P21	P41212
Cell dimensions (Å, °)	a = 81.5; b = 73.6; c = 37.1	a = 42.3; b = 41.4; c = 72.3; β = 104.4	a = 44.7; b = 44.7; c = 222.6	a = 89.5; b = 47.7; c = 141.0; β = 106.3	a = 57.7; b = 80.0; c = 133.4	a = 69.7; b = 97.7; c = 82.4	a = 57.9; b = 102.7; c = 109.0	a = 146.7; b = 44.6; c = 85.2; β = 94.1	a = 57.8; b = 58.2; c = 72.1; β = 92.4	a = 88.6; b = 88.6; c = 108.9
Oligomeric state	Monomer	Monomer	Monomer	Monomer	Monomer	Monomer	Monomer	Dimer	Monomer	Monomer
identity to CA II	61	-	58	34	35	56	34	36	61	37
Rmsd to CA II (Å)	0.9	-	0.8	1.3	1.4	0.6	1.4	1.2	0.8	1.2

To date, no crystal structures of CA VA, CAVB, CA X, or CA XI have been deposited in the PDB.