Table of Contents
International Journal of Molecular Imaging
Volume 2011, Article ID 195037, 9 pages
Research Article

The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification

1Nuclear Medicine, Faculty of Health Sciences, Stellenbosch University and Tygerberg Hospital, Tygerberg, 7505, Cape Town, South Africa
2MRC Unit for Stress and Anxiety Disorders, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa
3Laboratory for Cognitive Neurology and Medical Imaging Research Center, KU 3000 Leuven, Belgium

Received 30 July 2010; Revised 12 January 2011; Accepted 13 February 2011

Academic Editor: Georges El Fakhri

Copyright © 2011 J. M. Warwick et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Striatal single photon emission computed tomography (SPECT) imaging of the dopaminergic system is becoming increasingly used for clinical and research studies. The question about the value of nonuniform attenuation correction has become more relevant with the increasing availability of hybrid SPECT-CT scanners. In this study, the value of nonuniform attenuation correction and correction for collimator blurring were determined using both phantom data and patient data. Methods. SPECT imaging was performed using 7 anthropomorphic phantom measurements, and 14 patient studies using [I-123]-FP-CIT (DATSCAN). SPECT reconstruction was performed using uniform and nonuniform attenuation correction and collimator blurring corrections. Recovery values (phantom data) or average-specific uptake ratios (patient data) for the different reconstructions were compared at similar noise levels. Results. For the phantom data, improved recovery was found with nonuniform attenuation correction and collimator blurring corrections, with further improvement when performed together. However, for patient data the highest average specific uptake ratio was obtained using collimator blurring correction without nonuniform attenuation correction, probably due to subtle SPECT-CT misregistration. Conclusions. This study suggests that an optimal brain SPECT reconstruction (in terms of the lowest bias) in patients would include a correction for collimator blurring and uniform attenuation correction.