Table of Contents
International Journal of Molecular Imaging
Volume 2011 (2011), Article ID 283497, 10 pages
http://dx.doi.org/10.1155/2011/283497
Review Article

Towards In Vivo Imaging of Cancer Sialylation

1Human Glycobiology Laboratory, Science Faculty, Autonomous University of the State of Morelos, Avenida Universidad 1001, Col. Chamilpa, 62209 Cuernavaca, MOR, Mexico
2The Molecular Imaging Commission of the Mexican Academy of Surgery, Zacatecas 230-502, Colonia Roma, 06700 Mexico, DF, Mexico

Received 2 May 2011; Accepted 14 June 2011

Academic Editor: Lie-Hang Shen

Copyright © 2011 Ivan Martinez-Duncker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In vivo assessment of tumor glucose catabolism by positron emission tomography (PET) has become a highly valued study in the medical management of cancer. Emerging technologies offer the potential to evaluate in vivo another aspect of cancer carbohydrate metabolism related to the increased anabolic use of monosaccharides like sialic acid (Sia). Sia is used for the synthesis of sialylated oligosaccharides in the cell surface that in cancer cells are overexpressed and positively associated to malignancy and worse prognosis because of their role in invasion and metastasis. This paper addresses the key points of the different strategies that have been developed to image Sia expression in vivo and the perspectives to translate it from the bench to the bedside where it would offer the clinician highly valued complementary information on cancer carbohydrate metabolism that is currently unavailable in vivo.