Table of Contents
International Journal of Molecular Imaging
Volume 2011, Article ID 796025, 15 pages
Review Article

Molecular SPECT Imaging: An Overview

1Biological Imaging Centre, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
2Nuclear Medicine Section, Medical Imaging Department, King Fahad Specialist Hospital, P.O. Box 11757, Dammam 31463, Saudi Arabia

Received 1 August 2010; Accepted 5 February 2011

Academic Editor: Hiroshi Watabe

Copyright © 2011 Magdy M. Khalil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Molecular imaging has witnessed a tremendous change over the last decade. Growing interest and emphasis are placed on this specialized technology represented by developing new scanners, pharmaceutical drugs, diagnostic agents, new therapeutic regimens, and ultimately, significant improvement of patient health care. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have their signature on paving the way to molecular diagnostics and personalized medicine. The former will be the topic of the current paper where the authors address the current position of the molecular SPECT imaging among other imaging techniques, describing strengths and weaknesses, differences between SPECT and PET, and focusing on different SPECT designs and detection systems. Radiopharmaceutical compounds of clinical as well-preclinical interest have also been reviewed. Moreover, the last section covers several application, of 𝜇 SPECT imaging in many areas of disease detection and diagnosis.