Table of Contents
International Journal of Molecular Imaging
Volume 2011 (2011), Article ID 803920, 7 pages
http://dx.doi.org/10.1155/2011/803920
Review Article

Role of Single Photon Emission Computed Tomography in Epilepsy

1Department of Neurology, Krishna Institute of Medical Sciences, 1-8-31/1, Minister Road, Secunderabad, Andhra Pradesh 500 003, India
2Department of Nuclear Medicine, Krishna Institute of Medical Sciences, Hyderabad, 1-8-31/1, Minister Road, Secunderabad, Andhra Pradesh 500 003, India
3Department of Neurosurgery, Krishna Institute of Medical Sciences, Hyderabad, 1-8-31/1, Minister Road, Secunderabad, Andhra Pradesh 500 003, India

Received 1 August 2010; Accepted 25 October 2010

Academic Editor: Abass Alavi

Copyright © 2011 Sita Jayalakshmi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Molecular imaging with ictal single photon emission computed tomography (SPECT) is an established functional imaging modality for the presurgical evaluation of patients with refractory partial onset seizures. SPECT coregistered on to the MRI has greater sensitivity to identify the ictal onset zone. Ictal SPECT should always be interpreted in the context of other presurgical investigations. Ictal SPECT is sensitive method for the lateralization of TLE, but ictal SPECT is more sensitive when MRI is normal. Ictal SPECT and interictal PET are complementary to each other in lateralizing the side in patients with TLE and normal MRI. In extratemporal epilepsy, ictal SPECT will guide the placement of surface grid and depth electrodes.