Concurrent Dual Contrast for Cellular Magnetic Resonance Imaging Using Gadolinium Oxide and Iron Oxide Nanoparticles

Table 1

Cellular uptake of iron (Fe) or gadolinium (Gd) measured on ICP-AES.

Incubation medium [Fe] (mM)	Mass of Fe (pg/cell)	Incubation medium [Gd] (mM)	Mass of Gd (pg/cell)
0	0	0	0
0.0036	0.77	0.002	0.71
0.009	1.87	0.02	7.26
0.018	3.21	0.1	34.1
0.036	6.17	0.2	84.9

A linear correlation exists between Fe incubation concentration and cellular uptake (𝑟=0.9997, 𝑃<1𝑒−6) and between Gd incubation concentration and cellular uptake (𝑟=0.995, 𝑃<1𝑒−4).