Table of Contents
International Journal of Molecular Imaging
Volume 2012 (2012), Article ID 253475, 7 pages
http://dx.doi.org/10.1155/2012/253475
Clinical Study

Comparative Analysis between SPECT Myocardial Perfusion Imaging and CT Coronary Angiography for Diagnosis of Coronary Artery Disease

1Department of Nuclear Medicine, Tianjin Medical University, Cardiovascular Clinical Institute and TEDA International Cardiovascular Hospital, Tianjin 300457, China
2Department of Radiology, Tianjin Medical University, Cardiovascular Clinical Institute and TEDA International Cardiovascular Hospital, Tianjin 300457, China

Received 31 March 2012; Revised 5 June 2012; Accepted 5 June 2012

Academic Editor: Domenico Rubello

Copyright © 2012 Jian-ming Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study aims to discuss the relationship and difference between myocardial perfusion imaging (MPI) using SPECT and CT coronary angiography (CTCA) for diagnosis of coronary artery disease (CAD). Five hundred and four cases undergoing MPI and CTCA were comparatively analyzed, including fifty six patients undergoing invasive coronary angiography in the same period. Among patients with negative MPI results, negative or positive CTCA occupied 84.7% or 15.3%, respectively. Among patients with positive MPI, positive or negative CTCA occupied 67.2% or 32.8%, respectively. Among patients with negative CTCA, negative or positive MPI occupied 94.4% or 5.6%, respectively. Among patients with positive CTCA, positive or negative MPI occupied 40.2% or 59.8%, respectively. Negative predictive value was relatively higher than the positive predictive value for positive CTCA eliminating or predicting abnormal haemodynamics. And there was no significant difference for sensitivity, specificity, and accuracy of MPI or CTCA in diagnosing CAD. Both MPI and CTCA have good diagnostic performance for CAD. They provide different and complementary information for diagnosis and evaluation of CAD, namely, detection of ischemia versus detection of atherosclerosis, which are quite different but have a definite internal link for each other.