International Journal of Molecular Imaging

Research Article

Feasibility Evaluation of Radioimmunoguided Surgery of Breast Cancer

Table 1

Published tumour-to-background activity concentration ratios achieved for radiopharmaceuticals used to target TAAs in breast cancer.
Tumour-associated antigenTumour-to-background activity (T:B)Reference
111In-B72.3 (TAG-72) 4 . 3 ± 0 . 9 1 i [15]
111In-Trastuzumab (HER-2) 1 . 3 − 9 . 3 i i [19]
111In-DTPA- T r a s t u z u m a b F a b (HER-2) 2 5 . 2 ± 1 . 6 2 i i i [16]
111In-benzyl-DOTA-Z (HER-2) 1 7 ± 2 . 3 i i i [17]
131I-CEA antibody 1 . 4 ± 0 . 3 i i [21]
i T :B ratio was determined using well chamber measurements of normal and cancerous tissue uptake in a series of mastectomy samples. i i T :B ratio was determined by gamma camera imaging of patients enrolled in a clinical trial, evaluating the tissue uptake in cancerous lesions and in background. i i i T :B ratio was determined using well chamber measurements of normal and cancerous tissue uptake from xenografted sacrificed mice.