Reproducible Analysis of Rat Brain PET Studies Using an Additional [¹⁸F]NaF Scan and an MR-Based ROI Template

Table 3

[¹¹C]AF150(S) uptake (%ID/g) derived from various brain regions by three observers following image coregistration.

Number of subjects (𝑛=10)
	Region
	Left striatum	Right striatum	Hippocampus	Frontal cortex	Posterior cortex	Medulla oblongata	Cerebellum	Mean COV
Observer 1
5 min	1.06 ± 0.16	1.04 ± 0.17	0.98 ± 0.16	0.95 ± 0.13	0.92 ± 0.14	0.67 ± 0.13	0.80 ± 0.14	16.12
10 min	0.70 ± 0.11	0.71 ± 0.11	0.67 ± 0.10	0.64 ± 0.11	0.64 ± 0.10	0.46 ± 0.08	0.53 ± 0.08	16.08
15 min	0.57 ± 0.09	0.57 ± 0.10	0.54 ± 0.09	0.52 ± 0.08	0.52 ± 0.08	0.38 ± 0.06	0.44 ± 0.07	15.96
30 min	0.33 ± 0.05	0.33 ± 0.05	0.32 ± 0.05	0.30 ± 0.05	0.31 ± 0.05	0.25 ± 0.04	0.27 ± 0.05	15.81
45 min	0.23 ± 0.04	0.23 ± 0.05	0.23 ± 0.04	0.21 ± 0.04	0.22 ± 0.04	0.18 ± 0.04	0.20 ± 0.04	18.49
Observer 2
5 min	1.05 ± 0.17	1.05 ± 0.18	0.99 ± 0.16	0.99 ± 0.17	0.95 ± 0.17	0.66 ± 0.12	0.80 ± 0.14	17.26
10 min	0.70 ± 0.12	0.72 ± 0.12	0.68 ± 0.11	0.67 ± 0.13	0.65 ± 0.12	0.47 ± 0.08	0.53 ± 0.09	17.19
15 min	0.57 ± 0.10	0.58 ± 0.10	0.55 ± 0.09	0.54 ± 0.10	0.53 ± 0.09	0.39 ± 0.06	0.44 ± 0.08	17.10
30 min	0.33 ± 0.05	0.33 ± 0.05	0.33 ± 0.05	0.31 ± 0.05	0.31 ± 0.05	0.24 ± 0.04	0.28 ± 0.05	16.67
45 min	0.23 ± 0.04	0.24 ± 0.04	0.23 ± 0.04	0.22 ± 0.04	0.22 ± 0.04	0.18 ± 0.03	0.20 ± 0.04	18.08
Observer 3
5 min	1.06 ± 0.16	1.04 ± 0.17	0.98 ± 0.15	0.93 ± 0.14	0.89 ± 0.14	0.71 ± 0.14	0.80 ± 0.14	16.44
10 min	0.70 ± 0.12	0.71 ± 0.12	0.67 ± 0.11	0.64 ± 0.11	0.61 ± 0.10	0.48 ± 0.07	0.53 ± 0.09	16.52
15 min	0.56 ± 0.09	0.57 ± 0.10	0.54 ± 0.09	0.51 ± 0.08	0.50 ± 0.08	0.40 ± 0.06	0.44 ± 0.07	16.51
30 min	0.32 ± 0.06	0.33 ± 0.05	0.32 ± 0.05	0.30 ± 0.05	0.29 ± 0.05	0.25 ± 0.04	0.28 ± 0.05	16.70
45 min	0.22 ± 0.04	0.23 ± 0.04	0.23 ± 0.04	0.21 ± 0.04	0.21 ± 0.04	0.19 ± 0.04	0.20 ± 0.04	18.86

Data represent mean ± SD (𝑛=10).