International Journal of Molecular Imaging

Research Article

Reproducible Analysis of Rat Brain PET Studies Using an Additional [¹⁸F]NaF Scan and an MR-Based ROI Template

Table 4

Intraclass correlation coefficients and corresponding 95% confidence intervals for regional [¹¹C]AF150(S) brain uptake (%ID/g).


Number of subjects ()
ROI	Observer 1 versus 2				Observer 1 versus 3
ROI	ICC_A	95% CL	ICC_C	95% CL	ICC_A	95% CL	ICC_C	95% CL

Left striatum	0.998	(0.991, 0.999)	0.997	(0.990, 0.999)	0.997	(0.988, 0.999)	0.997	(0.988, 0.999)
Right striatum	0.995	(0.978, 0.999)	0.995	(0.981, 0.999)	0.998	(0.991, 0.999)	0.998	(0.992, 0.999)
Hippocampus	0.997	(0.989, 0.999)	0.997	(0.989, 0.999)	0.992	(0.769, 0.999)	0.997	(0.989, 0.999)
Frontal cortex	0.930	(0.491, 0.985)	0.961	(0.853, 0.990)	0.985	(0.886, 0.997)	0.991	(0.963, 0.998)
Posterior cortex	0.956	(0.826, 0.989)	0.962	(0.856, 0.990)	0.927	(0.102, 0.987)	0.978	(0.913, 0.994)
Medulla oblongata	0.966	(0.879, 0.991)	0.967	(0.873, 0.992)	0.904	(−0.022, 0.984)	0.985	(0.940, 0.996)
Cerebellum	0.993	(0.972, 0.998)	0.992	(0.969, 0.998)	0.970	(0.499, 0.994)	0.988	(0.954, 0.999)

	Observer 2 versus 3				Overall
Left striatum	0.997	(0.988, 0.999)	0.997	(0.989, 0.999)	0.997	(0.992, 0.999)	0.997	(0.992, 0.999)
Right striatum	0.998	(0.991, 0.999)	0.997	(0.990, 0.999)	0.997	(0.990, 0.999)	0.997	(0.991, 0.999)
Hippocampus	0.987	(0.632, 0.998)	0.996	(0.983, 0.999)	0.992	(0.947, 0.998)	0.997	(0.991, 0.999)
Frontal cortex	0.907	(0.080, 0.983)	0.968	(0.878, 0.992)	0.937	(0.682, 0.985)	0.972	(0.922, 0.992)
Posterior cortex	0.856	(0.062, 0.971)	0.939	(0.776, 0.985)	0.911	(0.605, 0.979)	0.959	(0.885, 0.989)
Medulla oblongata	0.895	(0.306, 0.977)	0.945	(0.794, 0.986)	0.919	(0.608, 0.981)	0.966	(0.904, 0.991)
Cerebellum	0.957	(0.663, 0.991)	0.977	(0.910, 0.994)	0.974	(0.881, 0.994)	0.986	(0.960, 0.996)

Level of agreement: ≤0.40 poor to fair, 0.41–0.60 moderate, 0.61–0.80 substantial, 0.81–1.00 almost perfect.