Table 4: Intraclass correlation coefficients and corresponding 95% confidence intervals for regional [11C]AF150(S) brain uptake (%ID/g).

Number of subjects ( )
ROIObserver 1 versus 2Observer 1 versus 3
ICCA95% CLICCC95% CLICCA95% CLICCC95% CL

Left striatum0.998(0.991, 0.999)0.997(0.990, 0.999)0.997(0.988, 0.999)0.997(0.988, 0.999)
Right striatum0.995(0.978, 0.999)0.995(0.981, 0.999)0.998(0.991, 0.999)0.998(0.992, 0.999)
Hippocampus0.997(0.989, 0.999)0.997(0.989, 0.999)0.992(0.769, 0.999)0.997(0.989, 0.999)
Frontal cortex 0.930(0.491, 0.985)0.961(0.853, 0.990)0.985(0.886, 0.997)0.991(0.963, 0.998)
Posterior cortex 0.956(0.826, 0.989)0.962(0.856, 0.990)0.927(0.102, 0.987)0.978(0.913, 0.994)
Medulla oblongata0.966(0.879, 0.991)0.967(0.873, 0.992)0.904(−0.022, 0.984)0.985(0.940, 0.996)
Cerebellum0.993(0.972, 0.998)0.992(0.969, 0.998)0.970(0.499, 0.994)0.988(0.954, 0.999)

Observer 2 versus 3Overall
Left striatum0.997(0.988, 0.999)0.997(0.989, 0.999)0.997(0.992, 0.999)0.997(0.992, 0.999)
Right striatum0.998(0.991, 0.999)0.997(0.990, 0.999)0.997(0.990, 0.999)0.997(0.991, 0.999)
Hippocampus0.987(0.632, 0.998)0.996(0.983, 0.999)0.992(0.947, 0.998)0.997(0.991, 0.999)
Frontal cortex 0.907(0.080, 0.983)0.968(0.878, 0.992)0.937(0.682, 0.985)0.972(0.922, 0.992)
Posterior cortex 0.856(0.062, 0.971)0.939(0.776, 0.985)0.911(0.605, 0.979)0.959(0.885, 0.989)
Medulla oblongata0.895(0.306, 0.977)0.945(0.794, 0.986)0.919(0.608, 0.981)0.966(0.904, 0.991)
Cerebellum0.957(0.663, 0.991)0.977(0.910, 0.994)0.974(0.881, 0.994)0.986(0.960, 0.996)

Level of agreement: ≤0.40 poor to fair, 0.41–0.60 moderate, 0.61–0.80 substantial, 0.81–1.00 almost perfect.