Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy

Table 1

A summary of previous Intra-Tx tumour response assessment studies that used the Fixed size ROI method.

Study	𝑛	Site	Pre-Tx ROI	Intra-Tx ROI	Res. Thr
Schelling et al. (2000) [1]	22	Breast	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at max	55%
Weber et al. (2003) [2]	57	Lung	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at max	20%
Avril et al. (2005) [3]	33	Ovarian	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at max	20%
Brun et al. (2002) [4]	47	Head and neck	Fixed size, square (4 or 9 pixels) at max	Fixed size, square (4 or 9 pixels) at max	Median
Rousseau et al. (2006) [5]	64	Breast	Fixed size, 5 to 10 mm at max	Fixed size, 5 to 10 mm at max	40%
Maisonobe et al. (2013) [6]	40	Colorectal	Fixed size, 3×3×3 voxels at max	Fixed size, 3×3×3 voxels at max	N/Sp
Ott et al. (2006) [7]	65	EG junction	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at the same position using landmark	35%
Weber et al. (2001) [8]	40	EG junction	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at the same position using landmark	35%
Wieder et al. (2007) [9]	24	EG junction	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at the same position using landmark	35%
Ott et al. (2003) [10]	44	Gastric	Fixed size, circular 15 mm at max	Fixed size, circular 15 mm at the same position using landmark	35%
Wieder et al. (2004) [11]	38	Esophagus	Fixed size, circular 15 mm at max	N/Sp	30%
Schwarz et al. (2005) [12]	11	Breast	Fixed size, circular (size N/Sp) manually placed	Fixed size, circular (size N/Sp) manually placed	20%

 𝑛: number of patients, Pre-Tx: pretreatment, Intra-Tx: intratreatment, ROI: region of interest, Res. Thr.: response threshold, EG: esophagogastric, N/Sp: not specified.