Table of Contents
International Journal of Molecular Imaging
Volume 2013, Article ID 290750, 7 pages
http://dx.doi.org/10.1155/2013/290750
Research Article

Rhenium-188 Production in Hospitals, by W-188/Re-188 Generator, for Easy Use in Radionuclide Therapy

11st Radiology Department, National & Kapodistrian University of Athens, Athens, Greece
2Medical Physics Laboratory, School of Medicine, National & Kapodistrian University of Athens, Athens, Greece
3Radiation Physics Unit & Division of Nuclear Medicine, 1st Radiology Department, National & Kapodistrian University of Athens, Athens, Greece

Received 4 November 2012; Accepted 13 March 2013

Academic Editor: Sui Shen

Copyright © 2013 Maria Argyrou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rhenium-188 (Re-188) is a high energy -emitting radioisotope obtained from the tungsten-188/rhenium-188 (W-188/Re-188) generator, which has shown utility for a variety of therapeutic applications in nuclear medicine, oncology, and interventional radiology/cardiology. Re-188 decay is accompanied by a 155 keV predominant energy -emission, which could be detected by -cameras, for imaging, biodistribution, or absorbed radiation dose studies. Its attractive physical properties and its potential low cost associated with a long-lived parent make it an interesting option for clinical use. The setup and daily use of W-188/Re-188 generator in hospital nuclear medicine departments are discussed in detail. The clinical efficacy, for several therapeutic applications, of a variety of Re-188-labeled agents is demonstrated. The high energy of the -emission of Re-188 is particularly well suited for effective penetration in solid tumours. Its total radiation dose delivered to tissues is comparable to other radionuclides used in therapy. Furthermore, radiation safety and shielding requirements are an important subject of matter. In the case of bone metastases treatment, therapeutic ratios are presented in order to describe the efficacy of Re-188 usage.