Longitudinal Imaging of Cancer Cell Metastases in Two Preclinical Models: A Correlation of Noninvasive Imaging to Histopathology
Figure 1
In vitro bioluminescence characteristics of B16-F10-Luc and MDA-MB-231-Luc luciferase-expressing cell lines. Murine melanoma B16-F10-Luc ((a) and (b)) and human breast cancer MDA-MB-231-Luc ((c) and (d)) cell lines were serially diluted and imaged with 2 sec exposures for a maximum of up to 40-minute dynamic scan. Kinetic measurement of luciferase activity correlated with the cell density for both cell lines and luminescence activity increased with time. The assay was done in duplicate.
