Longitudinal Imaging of Cancer Cell Metastases in Two Preclinical Models: A Correlation of Noninvasive Imaging to Histopathology

Figure 2

Longitudinal monitoring of tumor growth at metastatic sites by bioluminescence imaging. B16-F10-Luc cells were intravenously injected into female C57 BL⧵6 mice (𝑛=5). (a) BLI of a representative animal imaged weekly for 4 weeks. (b) Plot representing quantification of bioluminescence intensity as total flux (photons/second) over 4 weeks for all 5 animals. (c) Three-dimensional reconstruction of DLIT of a representative animal at week 4. (d) Quantification of light intensity bioluminescent cells over 3 weeks from DLIT reconstruction.