^99mTechnetium Sestamibi-¹²³Iodine Scintigraphy Is More Accurate Than ^99mTechnetium Sestamibi Alone before Surgery for Primary Hyperparathyroidism

Table 3

Scintigraphic results compared with histopathological findings in 265 patients who had pathological gland(s) removed.

Histopathology	Patients	Cured (%)	Number of; pathological glands	Number (%) of positive glands; on ^123I-^99mTc-sestamibi scan	True positives^a; (% of all glands)	False positive^b ()
Single adenoma	218	206 (94)	218	176 (81)	165 (76)	11^c
Multiple adenomas	3	3	6	3 (50)	3 (50)	0
Hyperplasia (one gland in 10^d cases)	24	20	40	21 (52)	18 (45)	3
Hyperplasia or/and adenoma (one gland in 9 cases)	15	15	22	12 (54)	11 (50)	1
Carcinoma	3	3	3	2 (67)	2 (67)	0
Carcinoma and hyperplastic gland	2	2	5	3 (60)	3 (60)	0

A true positive finding is defined as scintigraphic finding on the same side as the operative finding, and the finding is histologically confirmed.
^bA false positive finding is defined as scintigraphic finding on the contralateral side compared to the operative finding.
^cOf these 11 patients, 7 had bilateral imaging findings and 4 had one unilateral finding on the wrong side of the neck.
^dOf the 10 patients with one hyperplastic gland removed at primary surgery, 4 were not cured as they had multiglandular disease, while 4 had single gland disease and were cured.