Radium-223 Therapy for Patients with Metastatic Castrate-Resistant Prostate Cancer: An Update on Literature with Case Presentation

Table 3

Case #3: summary of pertinent laboratory results and imaging findings.

Lab work/imaging; (normal values)	Baseline; (within 3 mo before Radium-223)	Interim; (between injections #3 and #4)	Completion; (within 3 mo after Radium-223)
Hb; (12.9–16.9/dL)	11.5	10.9	8.5
Platelets; (156–369 × 10^9/L)	231	273	157
Absolute neutrophils; (2.240–7.680 × 10^9/L)	4.3	5.3	5.5
PSA; (ng/mL)	33	119	597
Alkaline phosphatase; (38–126 IU/L)	56	69	246
Whole-body bone scan	Widespread bone metastases with the most intense lesions located along the T-spine, left skull, and ribs		Previous bone metastases show interval decrease in uptake. There are new bone metastases at other sites (upper T-spine, L-spine, pelvis, and ribs)
Diagnostic CT-chest, abdomen, and pelvis	Widespread bone metastases consistent with bone scan. Several small liver lesions suspicious for metastases. No evidence of lymphadenopathy		Stable osteoblastic metastases. New areas of mild osteosclerosis in T-spine and L- spine consistent with bone scan findings. Also, worsening of liver metastases and suspicious new pulmonary metastases