International Journal of Microbiology

Research Article

Functional Promiscuity of Homologues of the Bacterial ArsA ATPases

Table 1

ArsA homologues used to generate the phylogenetic tree. From left to right, the proteins are characterized according to cluster and abbreviation, organismal source, protein size, organismal type, and gi number. Within each cluster, proteins are presented according to position going clockwise around the tree.
Cluster and protein abbreviationsOrganismal sourceProtein size (no. of aas)Organismal typeGI no.
Cluster 1
Sep1Staphylococcus epidermidis RP62A565Firmicutes57865830
Esp2Exiguobacterium sp. AT1b585Firmicutes187604364
Lsp2Lysinibacillus sphaericus C3-41586Firmicutes169828142
Lpl1Lactobacillus plantarum WCFS1576Firmicutes54307196
Sdy1Streptococcus dysgalactiae subsp. equisimilis580Firmicutes157419736
Lla1Lactococcus lactis subsp. cremoris MG1363571Firmicutes125624073
Hin1Haemophilus influenzae PittHH597 145636206
Ahy1Anaerococcus hydrogenalis DSM 7454580Firmicutes212696774
Bth1Bacteroides thetaiotaomicron VPI-5482570Bacteroidetes29345526
Bco1Bacillus coagulans 36D1590Firmicutes124520553
Swo1Syntrophomonas wolfei subsp. wolfei str. Goettingen583Firmicutes114566470
Cte6Clostridium tetani E88589Firmicutes28211528
Cph2Clostridium phytofermentans ISDg582Firmicutes160880289
Dha1Desulfitobacterium hafniense Y51598Firmicutes89897344
Aor1Alkaliphilus oremlandii OhILAs582Firmicutes158320145
Cbe1Clostridium beijerinckii NCIMB 8052582Firmicutes150016979
Bse1Bacillus selenitireducens MLS10587Firmicutes163763208
Bce2Bacillus cereus ATCC 10987586Firmicutes44004495
Bsp2Bacillus sp. SG-1594Firmicutes149180106
Gur1Geobacter uraniireducens Rf4583 148263449
Bph1Burkholderia phytofirmans PsJN584 187925677
Mma1Magnetospirillum magnetotacticum MS-1574 46201533
Rru1Rhodospirillum rubrum ATCC 11170571 83592783
Bvi1Burkholderia vietnamiensis G4587 134293367
Asp4Azoarcus sp. BH72582 119898647
Rba1Rhodopirellula baltica SH 1593Planctomycetes32475953
Aeh2Alkalilimnicola ehrlichei MLHE-1571 114321857
Orf3delta proteobacterium MLMS-1592 94266138
Vba1Verrucomicrobiae bacterium DG1235584Verrucomicrobia198257295
Vha1Vibrio harveyi ATCC BAA-1116582 156973785
Sty1Salmonella typhimurium585 32470159
Ahy2Aeromonas hydrophila subsp. hydrophila ATCC 7966599 117618702
Ppr1Photobacterium profundum SS9590 54308735
Psp1Psychromonas sp. CNPT3602 90408036
Cfe1Chlorobium ferrooxidans DSM 13031591Chlorobi110598505
Psp2Pseudomonas sp. TS44585 170026534
Rfe1Rhodoferax ferrireducens T118589 89902424
Dar1Dechloromonas aromatica RCB590 71908250
Afa1Alcaligenes faecalis591 42741719
Pae1Pseudomonas aeruginosa588 187939925
Sen1Salmonella enterica subsp. enterica serovar Saintpaul str. SARA29586 167553198
Aar1Aromatoleum aromaticum EbN1592 56478279
Aca1Acidithiobacillus caldus612 60686969
Otr1Ochrobactrum tritici582 94483089
Pst2Providencia stuartii ATCC 25827594 188026271
Ssp2Shewanella sp. ANA-3588 117920786
Yin1Yersinia intermedia ATCC 29909586 77979455
Asp1Arthrobacter sp. FB24621Actinobacteria116668777
Mgi1Mycobacterium gilvum PYR-GCK589Actinobacteria145222246
Rer1Rhodococcus erythropolis585Actinobacteria33867198
Rle1Rhizobium leguminosarum bv. viciae 3841588 116254241
Pna1Polaromonas naphthalenivorans CJ2600 121606619
Asp2Acidovorax sp. JS42586 121594853
Hla2Halorubrum lacusprofundi ATCC 49239640Euryarchaeota153896608
Hsp4Halobacterium sp. NRC-1644Euryarchaeota10803670
Cluster 2
Mka1Methanopyrus kandleri AV19333Euryarchaeota20095116
Mst1Methanosphaera stadtmanae DSM 3091328Euryarchaeota84488998
Msm1Methanobrevibacter smithii ATCC 35061340Euryarchaeota148643230
Mth1Methanothermobacter thermautotrophicus str. Delta H324Euryarchaeota15679508
Mja1Methanocaldococcus jannaschii DSM 2661349Euryarchaeota15669329
Mma2Methanococcus maripaludis S2345Euryarchaeota45357726
Mae2Methanococcus aeolicus Nankai-3341Euryarchaeota150401428
Cluster 3
Tva1Trichomonas vaginalis G3297Trichomonada123416597
Tva2Trichomonas vaginalis G3292Trichomonada123451254
Yli1Yarrowia lipolytica CLIB122327Fungi50554649
Gze1Gibberella zeae PH-1341Fungi46136751
Ani1Aspergillus nidulans FGSC A4340Fungi67524903
Spo1Schizosaccharomyces pombe329Fungi19115182
Rgl1Rhodotorula glutinis339Fungi183396512
Uma1Ustilago maydis 521332Fungi71019509
Cci1Coprinopsis cinerea okayama7 130326Fungi169843560
Cne1Cryptococcus neoformans var. neoformans JEC21325Fungi58260906
Cal1Candida albicans SC5314350Fungi68468811
Sce1Saccharomyces cerevisiae354Fungi51013779
Tad1Trichoplax adhaerens339Metazoa196008131
Ppa2Physcomitrella patens subsp. patens365Viridiplantae168012492
Obr1Oryza brachyantha364Viridiplantae110430665
Ath2Arabidopsis thaliana345Viridiplantae8570442
Psi1Picea sitchensis374Viridiplantae116784166
Ddi1Dictyostelium discoideum AX4329Amoebozoa66800287
Api1Acyrthosiphon pisum339Metazoa193582608
Dre1Danio rerio341Metazoa50539666
Nve1Nematostella vectensis334Metazoa156398556
Spu1Strongylocentrotus purpuratus346Metazoa72050675
Dan1Drosophila ananassae336Metazoa194755601
Nvi1Nasonia vitripennis344Metazoa156537421
Aae3Aedes aegypti341Metazoa157128460
Tca1Tribolium castaneum330Metazoa91081505
Cel1Caenorhabditis elegans342Metazoa17557003
Bma1Brugia malayi344Metazoa170590260
Pte1Paramecium tetraurelia strain d4-2325Oligohymenophorea145545770
Tth1Tetrahymena thermophila SB210349Oligohymenophorea118401519
Tcr1Trypanosoma cruzi strain CL Brener359Trypanosomatidae71401129
Lma1Leishmania major strain Friedlin409Trypanosomatidae157865666
Tpa1Theileria parva strain Muguga361Apicomplexa71027033
Bbo1Babesia bovis T2Bo358Apicomplexa156082722
Pbe1Plasmodium berghei str. ANKA379Apicomplexa68071753
Cmu1Cryptosporidium muris RN66390Apicomplexa209879305
Cpa1Cryptosporidium parvum Iowa II366Apicomplexa126654216
Ehi1Entamoeba histolytica HM-1:IMSS327Amoebozoa67466277
Gla1Giardia lamblia ATCC 50803354Hexamitidae159119999
Cluster 4
Gur2Geobacter uraniireducens Rf4637 148264869
Ssp1Synechococcus sp. JA-3-3Ab684Cyanobacteria86605793
Mae1Microcystis aeruginosa PCC 7806633Cyanobacteria159025965
Nsp2Nostoc sp. PCC 7120635Cyanobacteria17229736
Nsp3Nodularia spumigena CCY 9414617Cyanobacteria119512417
Ama1Arthrospira maxima CS-328637Cyanobacteria209527482
Ter2Trichodesmium erythraeum IMS101626Cyanobacteria113475961
Npu1Nostoc punctiforme PCC 73102623Cyanobacteria186682498
Cluster 5
Zma2Zea mays374Viridiplantae195625344
Ath3Arabidopsis thaliana391Viridiplantae30697424
Vvi1Vitis vinifera422Viridiplantae147852937
Ppa1Physcomitrella patens subsp. patens359Viridiplantae168024699
Zma1Zea mays394Viridiplantae195645964
Ath1Arabidopsis thaliana411Viridiplantae30681260
Vvi2Vitis vinifera409Viridiplantae157343988
Ptr1Populus trichocarpa407Viridiplantae118487322
Cre1Chlamydomonas reinhardtii513Viridiplantae159488560
Olu1Ostreococcus lucimarinus CCE9901330Viridiplantae145350244
Cluster 6
Aba1Acidobacteria bacterium Ellin345634Acidobacteria94969437
Mxa1Myxococcus xanthus DK 1622655 108758691
Cluster 7
Hwa1Haloquadratum walsbyi DSM 16790312Euryarchaeota110668350
Orf2uncultured prokaryote 2E01B314none85372676
Nph1Natronomonas pharaonis DSM 2160317Euryarchaeota76801342
Nph2Natronomonas pharaonis DSM 2160370Euryarchaeota76801234
Hsp2Halobacterium sp. NRC-1347Euryarchaeota15789625
Hla3Halorubrum lacusprofundi ATCC 49239392Euryarchaeota153895127
Cluster 8
Cth5Chloroherpeton thalassium ATCC 35110405Chlorobi193215201
Cau4Chloroflexus aurantiacus J-10-fl399Chloroflexi163845724
Cte1Chlorobium tepidum TLS395Chlorobi21673808
Cth2Chloroherpeton thalassium ATCC 35110405Chlorobi193214297
Pae2Prosthecochloris aestuarii DSM 271404Chlorobi194332962
Cte3Chlorobium tepidum TLS398Chlorobi21672957
Plu2Pelodictyon luteolum DSM 273406Chlorobi78185960
Cte2Chlorobium tepidum TLS405Chlorobi21674757
Cth4Chloroherpeton thalassium ATCC 35110402Chlorobi193214011
Cau1Chloroflexus aurantiacus J-10-fl390Chloroflexi163846065
Dau1Candidatus Desulforudis audaxviator MP104C397Firmicutes169830523
Ame1Alkaliphilus metalliredigens QYMF391Firmicutes150389286
Bce1Bacillus cereus ATCC 10987392Firmicutes42779427
Rxy1Rubrobacter xylanophilus DSM 9941394Actinobacteria108804153
Pae3Prosthecochloris aestuarii DSM 271395Chlorobi194333066
Cte4Chlorobium tepidum TLS394Chlorobi21674880
Cli1Chlorobium limicola DSM 245395Chlorobi189347837
Sel1Synechococcus elongatus PCC 7942392Cyanobacteria81300068
Gvi1Gloeobacter violaceus PCC 7421394Cyanobacteria37520959
Adi1Angiococcus disciformis405 53747901
Hsp1Hydrogenobaculum sp. Y04AAS1397Aquificae195953882
Aae2Aquifex aeolicus VF5396Aquificae15606091
Hsp5Hydrogenivirga sp. 128-5-R1-1393Aquificae163783049
Sus1Solibacter usitatus Ellin6076395Acidobacteria116624985
Dal1Desulfatibacillum alkenivorans AK-01397 163725491
Hau1Herpetosiphon aurantiacus ATCC 23779391Chloroflexi159900394
Rsp1Roseiflexus sp. RS-1396Chloroflexi148655082
Cau3Chloroflexus aurantiacus J-10-fl401Chloroflexi163848482
Cth3Chloroherpeton thalassium ATCC 35110383Chlorobi193214006
Cte7Chlorobium tepidum TLS384Chlorobi21674751
Cluster 9
Mma4Microscilla marina ATCC 23134390Bacteroidetes124004922
Pto1Picrophilus torridus DSM 9790386Euryarchaeota48478270
Tac1Thermoplasma acidophilum DSM 1728387Euryarchaeota16081559
Cph3Clostridium phytofermentans ISDg385Firmicutes160879841
Fnu2Fusobacterium nucleatum subsp. nucleatum ATCC 25586388Fusobacteria19704869
Cph1Clostridium phytofermentans ISDg393Firmicutes160879840
Fnu1Fusobacterium nucleatum subsp. nucleatum ATCC 25586396Fusobacteria19704870
Cluster 10
Nsp1Nocardioides sp. JS614410Actinobacteria119717335
Jsp1Janibacter sp. HTCC2649421Actinobacteria84496160
Ser1Saccharopolyspora erythraea NRRL 2338400Actinobacteria134098280
Nfa1Nocardia farcinica IFM 10152436Actinobacteria54023683
Mab1Mycobacterium abscessus423Actinobacteria169629069
Mle1Mycobacterium leprae TN415Actinobacteria15827412
Msp1Mycobacterium sp. MCS421Actinobacteria108800245
Msm2Mycobacterium smegmatis str. MC2 155425Actinobacteria118471162
Cluster 11
Cth1Chloroherpeton thalassium ATCC 35110434Chlorobi193214353
Cte5Chlorobium tepidum TLS436Chlorobi21673187
Cau2Chloroflexus aurantiacus J-10-fl407Chloroflexi163845728
Cth6Candidatus Chloracidobacterium thermophilum420Acidobacteria157273534
Cluster 12
Ter1Trichodesmium erythraeum IMS101364Cyanobacteria113474690
Bba1Bdellovibrio bacteriovorus HD100357 42525090
Cluster 13
Mmy1Mycoplasma mycoides subsp. mycoides LC str. GM12304Tenericutes188159217
Esp1Exiguobacterium sp. AT1b279Firmicutes187605346
Cluster 14
Iho1Ignicoccus hospitalis KIN4/I309Crenarchaeota156938113
Sma1Staphylothermus marinus F1329Crenarchaeota126465059
Tba1Thermococcus barophilus MP330Euryarchaeota197627410
Tko1Thermococcus kodakarensis KOD1331Euryarchaeota57640929
Pab1Pyrococcus abyssi GE5330Euryarchaeota14521447
Ton1Thermococcus onnurineus NA1330Euryarchaeota212224056
Cluster 15
Par1Pyrobaculum arsenaticum DSM 13514334Crenarchaeota145591126
Sth2Symbiobacterium thermophilum IAM 14863339Firmicutes51891819
Par2Pyrobaculum arsenaticum DSM 13514327Crenarchaeota145591125
Sth1Symbiobacterium thermophilum IAM 14863345Firmicutes51891818
Cluster 16
Wsu1Wolinella succinogenes DSM 1740313ε34557874
Aae1Aquifex aeolicus VF5299Aquificae15605857
Hsp3Hydrogenivirga sp. 128-5-R1-1306Aquificae163782204
Cluster 17
Csa1Chromohalobacter salexigens DSM 3043313 92114127
Bsp1Bacillus sp. NRRL B-14911328Firmicutes89098562
Bha1Bacillus halodurans C-125313Firmicutes15614358
Oih1Oceanobacillus iheyensis HTE831307Firmicutes23098830
Hha1Halorhodospira halophila SL1311 121998972
Aeh1Alkalilimnicola ehrlichei MLHE-1318 114319474
Tfu1Thermobifida fusca YX301Actinobacteria72161795
Nmo1Nitrococcus mobilis Nb-231311 88811608
Nph3Natronomonas pharaonis DSM 2160318Euryarchaeota76801557
Hwa2Haloquadratum walsbyi DSM 16790327Euryarchaeota110667012
Hla1Halorubrum lacusprofundi ATCC 49239341Euryarchaeota153896540
Hma1Haloarcula marismortui ATCC 43049426Euryarchaeota55379238
Cluster 18
Par3Psychrobacter arcticus 273-4339 71065679
Psp3Psychrobacter sp. PRwf-1331 148653012
Asp3Alcanivorax sp. DG881347 196196123
Ilo1Idiomarina loihiensis L2TR336 56459808
Iba1Idiomarina baltica OS145338 85712073
Pst1Pseudomonas stutzeri A1501335 146280770
Bli1Brevibacterium linens BL2327Actinobacteria62424272