Frequency of Drug Resistance Gene Amplification in Clinical Leishmania Strains

Table 2

Main characteristics of the isolates and results of relative quantification of resistance genes for Sudanese patients. All patients were visceral leishmaniasis patients except S28, S29, and S30 who presented with post kala-azar dermal leishmaniasis. NA: nonamplified.

Patients	Parasite identification	Site of isolation	PGP	MDR	GSH	DHFR	PTR1
S1	L. donovani MON 18	lymph node	0.98	1.21	0.85	1.01	1.03
S2	L. donovani MON 18	lymph node	4.47	19.4	2.93	0.93	1.49
S3	L. donovani MON 18	lymph node	1.28	2.71	0.92	0.98	0.85
S4	L. donovani MON 18	lymph node	0.78	1.21	1.04	1.03	2.03
S5	L. donovani MON 18	lymph node	0.97	6.16	1.61	1.02	1.03
S6	L. donovani MON 18	lymph node	0.8	5.49	0.62	0.75	0.86
S7	L. donovani MON 18	lymph node	0.82	NA	1.02	1.05	1.02
S8	L. donovani MON 18	lymph node	NA	0.96	0.85	NA	0.91
S9	L. donovani MON 18	lymph node	NA	0.78	0.95	NA	0.85
S10	L. donovani MON 18	lymph node	1.05	0.99	0.61	1.02	1.05
S11	L. donovani MON 18	lymph node	4.54	1.02	0.69	NA	NA
S12	L. donovani MON 18	lymph node	1.52	1.48	NA	1.07	0.98
s 13	L. donovani MON 18	lymph node	1.07	1.74	NA	NA	NA
S14	L. donovani MON 18	lymph node	1.17	2.72	1.04	0.98	2.7
S15	L. donovani MON 18	lymph node	0.94	4.68	0.95	0.95	0.86
S16	L. archibaldi MON 257	lymph node	0.87	0.98	1.04	1.02	NA
S17	L. archibaldi MON 257	lymph node	0.81	5.25	0.72	1.05	1.04
S18	L. archibaldi MON 258	lymph node	1.06	2.7	0.77	0.97	NA
S19	L. archibaldi MON 257	lymph node	0.92	1.33	0.98	0.85	0.83
S20	L. archibaldi MON 257	lymph node	1.13	4.47	0.79	1.03	NA
S21	L. archibaldi MON 257	lymph node	1.55	2.24	0.87	0.93	NA
S22	L. infantum MON 30	lymph node	7.83	3.62	1.12	0.83	0.97
S23	L. infantum MON 30	lymph node	0.99	1.74	0.77	0.92	NA
S24	L. infantum MON 30	lymph node	0.72	2.96	1.04	0.73	0.68
S25	L. infantum MON 30	lymph node	1.32	3.12	0.67	0.94	NA
S26	L. infantum MON 30	lymph node	1.04	1.03	1.01	1.02	NA
S27	L. infantum MON 30	lymph node	0.78	0.96	0.97	1.05	NA
S28	L. infantum MON 267	skin	0.93	7.13	2.48	0.95	NA
S29	L. donovani MON 18	skin	0.94	1.51	1.03	1.04	NA
S30	L. donovani MON 18	skin	22.2	62.8	1.83	0.63	1.1