Figure 1: Schematic overview of fungal biofilm resistance mechanisms. Generic overview of key biofilm resistance mechanisms associated with C. albicans, but which are likely to be common to other fungi. This figure illustrates the density and complexity of the C. albicans biofilm, with different morphotypes present surrounded by ECM. The arrows represent the different factors that drive antifungal resistance within the biofilm, including density, stress, persisters, ECM, efflux, overexpressed targets, and the general physiology of the biofilm. These have been placed according to their contribution to resistance, with those that have a greater effect closer to the middle and those with less impact at the edges.