Review Article
Antifungal Resistance and New Strategies to Control Fungal Infections
Table 3
Cis-acting elements involved in drug resistance.
| | Organism | Gene | Regulatory element | Position respectively to the ATG | Trans-acting factor | | | | Name | Sequence | | |
|
ABC transporters | | | BEE | — | −960 to −710 | ? | | | DRE | ACGGATATCGGATATTTTTTT | −460 to −439 | Tac1 | | CDR1 | NRE | CTGATTGA | −335 to −328 | ? | C. albicans | | SRE1 | GGAGTAGCAAGTGTGTCAAGAACCTGAATTC | −740 to −711 | ? | | | SRE2 | TTATCCGAAACGCTTTACTCCTCTATTATT | −691 to −661 | ? | | CDR2 | DRE | ACGGAAATCGGATATTTTTTT | −221 to −201 | Tac1 | C. glabrata | CgCDR1 | PDRE | TTCCGTGGAA | −1201 to −1192 | CgPdr1 | CgCDR2 | PDRE | TTCCGTGGAA | −560 to −551 | CgPdr1 |
|
MFS transporters | | | HRE/YRE | — | −561 to −520 | Cap1/? | | | BRE/ MDRE | ACGGTAAAATCCTAATTGGGAAAAATACCGAGAATGA | −296 to −260 | Mcm1/Mrr1 | C. albicans | CaMDR1 | AR1 | — | −397 to –301 | ? | | | AR2 | — | −588 to –500 | ? | | | AR3 | — | −287 to −209 | ? | C. glabrata | CgFLR1 | YRE3 | TTAGTAA | −372 to −366 | CgAp1 |
|
ERG11 | C. albicans | ERG11 | ARE | AATATCGTACCCGATTATGTCGTATATT | −224 to −251 | Upc2 | C. glabrata | ERG11 | SRE | | | Upc2A |
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