Cotrimoxazole Prophylaxis Specifically Selects for Cotrimoxazole Resistance in Streptococcus mutans and Streptococcus sobrinus with Varied Polymorphisms in the Target Genes folA and folP

Table 2

Comparison of the different antibiotic susceptibilities of the nonprophylaxis and prophylaxis groups*.

Antibiotic		STX prophylaxis use		OR	95% CI
		No; 𝑛 (%)	Yes; 𝑛 (%)
Cotrimoxazole	S	71 (84.5)	29 (45.3)	6.59	2.89–15.37
	R	13 (15.5)	35 (54.7)
Amoxicillin	S	61 (72.6)	41 (64.1)	1.49	0.02–118.67
	R	1 (1.2)	1 (1.6)
	I	22 (26.2)	22 (34.4)
Tetracycline	S	38 (45.2)	38 (59.4)	0.50	0.22–1.15
	R	30 (35.7)	15 (23.4)
	I	16 (19.0)	11 (17.2)
Erythromycin	S	74 (88.1)	49 (76.6)	3.02	0.63–19.37
	R	3 (3.6)	6 (9.4)
	I	7 (8.3)	9 (14.1)
Chloramphenicol	S	72 (85.7)	54 (84.4)	1.07	0.2–5.21
	R	5(6)	4 (6.3)
	I	7 (8.3)	6 (9.4)
Ceftriaxone	S	46 (54.8)	50 (78.1)	0.41	0.17–0.96
	R	27 (32.1)	12 (18.8)
	I	11 (13.1)	2 (3.1)

S: susceptible; R: resistant; *Intermediate resistance was not used in calculating OR.